Mitochondrial genome: Synthesis and recycling in one

A new research article by Wolfram Kunz’s group is published in Nature Communications. Viktoriya Peeva and Daniel Blei under the guidance of Gábor Zsurka and Wolfram Kunz describe the unexpected finding that enzymes well known for their role in replication of the mitochondrial DNA are also able to rapidly degrade damaged DNA species. Intact mitochondrial DNA is an absolute requirement for neuronal energy production. Thus, disturbance in its quality control can lead to neuronal dysfunction and, among others, epilepsy. Valuable contribution to the study came from students of the Master Program Neurosiences at the University Bonn as well as colleagues from the Universities of Cambridge and Cologne.

Find the article here.