Novel Optogenetic Tool for potassium-based silencing published in Nature Communications

IEECR scientists have participated in the development of a new optogenetic silencing tool for neuroscience, together with colleagues from the Humboldt-University Berlin, the Charité Berlin, Research Center Caesar, Freiburg and Martinsried. The two-component tool is based on the expression of both a photoactivated enzyme producing cAMP, and a cAMP sensitive bacterial potassium channel. A brief pulse of light causes production of cAMP and activation of the potassium channel, inducing powerful cellular activity suppression in neurons and heart cells.

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