A simple model suggesting economically rational sample-size choice drives irreproducibility

A new modeling study from Oliver Braganza (Beck group) explores the economic drivers of scientific sample size choice. The model suggests that economic pressures might be one reason for widespread and persistent underpowering of research, contributing to irreproducibility across disciplines. It further suggests ways to align economically and scientifically optimal behavior, including an increased focus on confirmatory research and addressing positive publication bias.

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