Beckonert, N. M., Opitz, T., Pitsch, J., da Silva, P., Beck, H. (2018) Polyamine modulation of anticonvulsant drug response: A potential mechanism contributing to pharmacoresistance in chronic epilepsy. J. Neuroscience. 13 June 2018, 38 (24) 5596-5605 (PubMed)

Braganza, O., Beck, H. (2018) The circuit motif as conceptual tool for multilevel neuroscience. Trends Neurosci. 41: 128-136. (PubMed)

Becker, A.J., Beck, H. (2018) New developments in understanding focal cortical malformations. Curr. Opin. Neurobiol. 31: 151-155. (pdf)


Taha, O., Opitz, T., Müller, M., Pitsch, J., Becker, A., Evert, B.O., Beck, H., Jeub, M. (2017) Neuropathic pain in experimental autoimmune neuritis is associated with altered electrophysiological properties of nociceptive DRG neurons. Exp. Neurol., 297: 25-35. (PubMed)

Holtkamp, D., Opitz, T., Niespodziany, I., Wolff, C., Beck, H. (2017) Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na+ channel inactivation. Epilepsia, 58: 27-41. (PubMed)

Kelly, T., Beck, H. (2017) Functional properties of granule cells with hilar basal dendrites in the epileptic dentate gyrus. Epilepsia, 58: 160-171. (PubMed)


Pitkänen, A., Löscher, W., Vezzani, A., Becker, A.J., Simonato, M., Lukasiuk, K., Gröhn, O., Bankstahl, J.P., Friedman, A., Aronica, E., Gorter, J.A., Ravizza, T., Sisodiya, S.M., Kokaia, M., Beck, H. (2016) Advances in the development of biomarkers for epilepsy. Lancet Neurol., 15: 843-856. (pdf)

Pabst, M., Braganza, O., Dannenberg, H., Hu, W., Pothmann, L., Rosen, J., Mody, I., van Loo, K., Deisseroth, K., Becker, A.J., Schoch, S., Beck, H. (2016) Astrocyte intermediaries of septal cholinergic modulation in the hippocampus. Neuron, 90: 853-865. (PubMed) Featured in: Science Signalling, Editors Choice. (2016) Astrocytes help make memories. Sci. Signal., 9: ec126. (pdf)


Royeck, M., Kelly, T., Opitz, T., Otte, D.M., Rennhack, A., Woitecki, A., Pitsch, J., Becker, A., Schoch, S., Kaupp, U.B., Yaari, Y., Zimmer, A., Beck, H. (2015) Downregulation of spermine augments dendritic persistent sodium currents and synaptic integration after status epilepticus. J. Neurosci., 35: 15240-15253. (PubMed)

Van Loo, K.M.J., Schaub, C., Pitsch, J., Kulbida, R., Opitz, T., Ekstein, D., Dalal, A., Urbach, H., Beck, H., Yaari, Y., Schoch, S., Becker, A.J. (2015) Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nature Comm., 6: 8688. (pdf)

Kabanova, A., Pabst, M., Lorkowski, M., Braganza, O., Boehlen, A., Nikbakht, N., Pothmann, L., Vaswani, A.R., Musgrove, R., Di Monte, D.A., Sauvage, M., Beck, H., Blaess, S. (2015) Function and developmental origin of a mesocortical inhibitory circuit. Nat. Neurosci., 18: 872-882. (PubMed)

Dannenberg, H., Pabst, M., Braganza, O., Schoch, S., Niediek, J., Bayraktar, M., Mormann, F., Beck, H. (2015) Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks. J. Neurosci., 35: 8394-8410. (PubMed)

Lennarz, S., Alich, T.C., Kelly, T., Blind, M., Beck, H., Mayer, G. (2015) Selective aptamer-based control of intraneuronal signaling. Angew. Chemie, 54: 5369-5373. (PubMed)

Doeser, A., Dickhof, G., Reitze, M., Uebachs, M., Schaub, C., Pires, N.M., Bonifácio M.J., Soares da Silva, P., Beck, H. (2015) Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug. Brain, 138: 371-387. (pdf)


Hedrich, U.B., Liautard, C., Kirschenbaum, D., Pofahl, M., Lavigne, J., Liu, Y., Theiss, S., Slotta, J., Escayg, A., Dihné, M., Beck, H., Mantegazza, M., Lerche, H. (2014) Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human NaV1.1 mutation. J. Neurosci., 34: 14874-14889. (PubMed)

Thome, C., Kelly, T., Yanez, A., Schultz, C., Engelhardt, M., Campbridge, S.B., Both, M., Draguhn, A., Beck, H., Egorov, A.V. (2014) Axon-carrying dendrites convey privileged synaptic input in hippocampal neurons. Neuron, 83: 1418-1430. (PubMed)

Pothmann, L., Müller, C., Averkin, R.G., Bellistri, E., Miklitz, C., Uebachs, M., Remy, S., Menendez de la Prida, L., Beck, H. (2014) Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs. J. Neurosci., 34: 9720-9735. (PubMed)

Doeser, A., Soares-da-Silva, P., Beck, H., Uebachs, M. (2014) The effects of eslicarbazepine on persistent Na⁺ current and the role of the Na⁺ channel β subunits. Epilepsy Res., 108: 202-211. (PubMed)

Pradier, B., Jeub, M., Markert, A., Mauer, D., Tolksdorf, K., Van de Putte, T., Seuntjens, E., Gailus-Durner, V., Fuchs, H., Jeub, M., Hrabě de Angelis, M., Huylebroeck, D., Beck, H., Zimmer, A., Rácz, I. (2014) Smad-interacting protein 1 affects acute and tonic, but not chronic pain.  Eur. J. Pain, 18: 249-257. (PubMed)


Klatte, K., Kirschstein, T., Otte, D., Pothmann, L., Müller, L., Tokay, T., Kober, M., Uebachs, M., Zimmer, A., Beck, H. (2013) Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy. J. Neurosci., 33: 13066-13080. (PubMed)

Alvarez-Baron, E., Michel, K., Mittelstaedt, T., Opitz, T., Schmitz, F., Beck, H., Dietrich, D., Becker, A.J., Schoch, S. (2013) RIM3γ and RIM4γ are key regulators of neuronal arborization. J. Neurosci., 33: 824-839. (PubMed)


Uebachs, M., Albus, C., Opitz, T., Isom, L., Niespodziany, I., Wolff, C., Beck, H. (2012) Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents. Epilepsia, 53: 1959-1967. (PubMed)

Pitsch, J., Opitz, T., Borm, V., Woitecki, A., Staniek, M., Beck, H., Becker, A.J., Schoch, S. (2012) The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus. J. Neurosci., 32: 12384-12395. (PubMed)

Müller, C., Beck, H., Coulter, D., Remy, S. (2012) Inhibitory control of linear and supralinear dendritic excitation in CA1 pyramidal neurons. Neuron, 75: 851-864. (PubMed)

Surges, R., Kukley, M., Brewster, A., Rüschenschmidt, C., Schramm, J., Baram, T.Z., Beck, H., Dietrich, D. (2012) Hyperpolarization-activated cation current Iof dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochem. Biophys. Res. Commun., 420: 156-160. (pdf)

Van Loo, K.M., Schaub, C., Pernhorst, K., Yaari, Y., Beck, H., Schoch, S., Becker, A.J. (2012) Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J. Biol. Chem., 287: 15489-15501. (PubMed)

Beck, H., Yaari. Y. (2012) Antiepileptogenesis, Plasticity of AED Targets, Drug Resistance, and Targeting the Immature Brain. In: Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition. Eds. Noebels, J.L., Avoli, M., Rogawski, M.A., Olsen, R.W., Delgado-Escueta, A.V. Bethesda: National Center for Biotechnology Information, pp. 1077-1085. (PubMed)


Jeub, M., Emrich, M., Pradier, B., Taha, O., Gailus-Durner, V., Fuchs, H., de Angelis, M.H., Huylebroeck, D., Zimmer, A., Beck, H., Racz, I. (2011) The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain, 152: 2384-2398. (PubMed)

Krueppel, R., Remy, S., Beck, H. (2011) Dendritic integration in hippocampal dentate granule cells. Neuron, 71: 512-528. (PubMed)

Otte, D.M., Sommersberg, B., Kudin, A., Guerrero, C., Albayram, Ö., Filiou, M.D., Frisch, P., Yilmaz, Ö., Drews, E., Turck, C.W., Bilkei-Gorzó, A., Kunz, W.S., Beck, H., Zimmer, A. (2011) N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology, 36: 2233-2243. (PubMed)

Chen, S., Su, H., Yue, C., Remy, S., Royeck, M., Sochivko, D., Opitz, T., Beck, H., Yaari, Y. (2011) An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. J. Neurophysiol., 105: 117-129. (PubMed)


Barnes, S.J., Opitz, T., Merkens, M., Kelly, T., von der Brelie, C., Krueppel, R., Beck, H. (2010) Stable mossy fiber long-term potentiation requires calcium influx at the granule cell soma, protein synthesis, and microtubule-dependent axonal transport. J. Neurosci., 30: 12996-13004. (PubMed)

Coras, R., Siebzehnrubl, F.A., Pauli, E., Huttner, H.B., Njunting, M., Kobow, K., Villmann, C., Hahnen, E., Neuhuber, W., Weigel, D., Buchfelder, M., Stefan, H., Beck, H., Steindler, D.A., Blümcke, I. (2010) Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain, 133: 3359-3372. (pdf)

Wimmer, V.C., Reid, C.A., Mitchell, S., Richards, K.L., Scaf, B.B., Leaw, B.T., Hill, E.L., Royeck, M., Horstmann, M.-T., Cromer, B.A., Davies, P.J., Xu, R., Lerche, H., Berkovic, S.F., Beck, H., Petrou, S. (2010) Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J. Clin. Invest., 120: 2661-2671. (pdf)

Uebachs, M., Opitz, T., Royeck, M., Dickhof, G., Horstmann, M.-T., Isom, L.L., Beck, H. (2010) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J. Neurosci., 30: 8489-8501. (PubMed)

Remy, S., Beck, H., Yaari, Y. (2010) Plasticity of voltage-gated ion channels in pyramidal cell dendrites. Curr. Opin. Neurobiol. 20: 503-509. (pdf)


Remy, S., Csicsvari, J., Beck, H. (2009) Activity-dependent control of neuronal output by local and global dendritic spike attenuation. Neuron, 61: 906-916. (PubMed) Comment in ‘Neuron Previews’ by Tiago Branco and Michael Häusser.


Beck, H., Yaari, Y. (2008) Plasticity of intrinsic neuronal properties in CNS disorders. Nat. Rev. Neurosci., 9: 357-369. (PubMed)

Royeck, M., Horstmann, M.-T., Remy, S., Reitze, M., Yaari, Y., Beck, H. (2008) Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J. Neurophysiol., 100: 2361-2380. (PubMed)

Beck, H., Elger, C.E. (2008) Epilepsy research: a window onto function to and dysfunction of the human brain. Dialogues Clin. Neurosci., 10: 7-15. (PubMed)

Beck, H., Yaari, Y. (2008) Plasticity of intrinsic neuronal properties in CNS disorders. Nat. Rev. Neurosci., 9: 357-369. (PubMed)

Sisodiya, S.M., Beck, H., Löscher, W., Vezzani, A. (2008) Mechanisms of Drug Resistance. In: Epilepsy: A Comprehensive Textbook, Second Edition. Eds. Engel Jr., J., Pedley, T. A. Philadelphia: Lippincott Williams & Wilkins, pp. 1279-1289.

Mathern, G.W., Wilson, C.L., Beck, H. (2008) Hippocampal Sclerosis. In: Epilepsy: A Comprehensive Textbook, Second Edition. Eds. J. Engel, Jr. and T. A. Pedley. Philadelphia: Lippincott Williams & Wilkins, pp. 121-136.

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