OLDER PUBLICATIONS

2007

Eckhardt, M., Hedayati, K.K., Pitsch, J., Lüllmann-Rauch, R., Beck, H., Fewou, S.N., Gieselmann, V. (2007) Sulfatide storage in neurons causes hyperexcitability and axonal degeneration in a mouse model of metachromatic leukodystrophy. J. Neurosci., 27: 9009-9021. (PubMed)

Kirschstein, T., Bauer, M., Müller, L., Rüschenschmidt, C., Reitze, M., Becker, A.J., Schoch, S., Beck, H. (2007) Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J. Neurosci., 27: 7696-7704. (PubMed)

Bender, R.A., Kirschstein, T., Kretz, O., Brewster, A.L., Richichi, C., Rüschenschmidt, C., Shigemoto, R., Beck, H., Frotscher, M., Baram, T.Z. (2007) Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J. Neurosci., 27: 4697-4706. (PubMed)

Schaub, C., Uebachs, M., Beck, H. (2007) Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy. Epilepsia, 48: 1339-1350. (PubMed)

Müller, A., Kukley, M., Uebachs, M., Beck, H., Dietrich, D. (2007) Nanodomains of single Ca2+ channels contribute to action potential repolarization in cortical neurons. J. Neurosci., 27: 483-495. (PubMed)

Beck, H. (2007) Plasticity of antiepileptic drug targets. Epilepsia, 48 (Suppl. 1): 14-18. (PubMed)

2006

Wiese, C., Rolletschek, A., Kania, G., Navarrete-Santos, A., Anisimov, S.V., Steinfarz, B., Tarasov, K.V., Brugh, S.A., Zahanich, I., Rüschenschmidt, C., Beck, H., Blyszczuk, P., Czyz, J., Heubach, J.F., Ravens, U., Horstmann, O., St-Onge, L., Braun, T., Brüstle, O., Boheler, K.R., Wobus, A.M. (2006) Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro. Stem Cells, 24: 2085-2097. (PubMed)

Surges, R., Brewster, A.L., Bender, R.A., Beck, H., Feuerstein, T.J., Baram, T.Z. (2006) Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. Eur. J. Neurosci., 24: 94-104. (PubMed)

Uebachs, M., Schaub, C., Perez-Reyes, E., Beck, H. (2006) T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates. J. Physiol., 571: 519-536. (PubMed)

Rüschenschmidt, C., Chen, J., Becker, A., Riazanski, V., Beck, H. (2006) Functional properties and oxidative modulation of A-type K currents in hippocampal granule cells of control and chronically epileptic rats. Eur. J. Neurosci., 23: 675-685. (PubMed)

von der Brelie, C., Waltereit, R., Zhang, L., Beck, H., Kirschstein, T. (2006) Impaired synaptic plasticity in a rat model of tuberous sclerosis. Eur. J. Neurosci., 23: 686-692. (PubMed)

Remy, S., Beck, H. (2006) Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain, 129: 18-35. (pdf)

Heinemann, U., Kann, O., Remy, S., Beck, H. (2006) Novel mechanisms underlying drug resistance in temporal lobe epilepsy. Adv. Neurol., 97: 85-95. (PubMed)

2005

Yue, C., Remy, S., Su, H., Beck, H., Yaari, Y. (2005) Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. J. Neurosci., 25: 9704-9720. (PubMed)

Zhang, L., Kirschstein, T., Sommersberg, B., Merkens, M., Manahan-Vaughan, D., Elgersma, Y., Beck, H. (2005) Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II. J. Neurosci., 25: 7697-7707. (PubMed)

Müller, A., Kukley, M., Stausberg, P., Beck, H., Müller, W., Dietrich, D. (2005) Endogenous Ca2+ buffer concentration and Ca2+ microdomains in hippocampal neurons. J. Neurosci., 25: 558-565. (PubMed)

Rüschenschmidt, C., Koch, P.G., Brüstle, O., Beck, H. (2005) Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats. Epilepsia, 46 Suppl 5: 174-183. (PubMed)

2004

Remy, C., Remy, S., Beck, H., Swandulla, D., Hans, M. (2004) Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology, 47: 1102-1112. (pdf)

Bernard, C., Anderson, A., Becker, A., Poolos, N.P., Beck, H., Johnston, D. (2004) Acquired dendritic channelopathy in temporal lobe epilepsy. Science, 305: 532-535. (pdf, supplement)

Wernig, M., Benninger, F., Schmandt, T., Rade, M., Tucker, K.L., Büssow, H., Beck, H., Brüstle, O. (2004) Functional integration of embryonic stem cell-derived neurons in vivo. J. Neurosci., 24: 5258-5268. (PubMed)

Kirschstein, T., von der Brelie, C., Steinhäuser, M., Vinçon, A., Beck, H., Dietrich, D. (2004) L-CCG-I activates group III metabotropic glutamate receptors in the hippocampal CA3 region. Neuropharmacology, 47: 157-162. (pdf)

2003

Scheffler, B., Schmandt, T., Schröder, W., Steinfarz, B., Husseini, L., Wellmer, J., Seifert, G., Karram, K., Beck, H., Blümcke, I., Wiestler, O.D., Steinhäuser, C., Brüstle, O. (2003) Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures. Development, 130: 5533-5541. (pdf)

Bender, R.A., Soleymani, S.V., Brewster, A.L., Nguyen, S.T., Beck, H., Mathern, G.W., Baram, T.Z. (2003) Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J. Neurosci., 23: 6826-6836. (PubMed)

Benninger, F., Beck, H., Wernig, M., Tucker, K.L., Brüstle, O., Scheffler, B. (2003) Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures. J. Neurosci., 23: 7075-7083. (PubMed)

Dietrich, D., Kirschstein, T., Kukley, M., Pereverzev, A., von der Brelie, C., Schneider, T., Beck, H. (2003) Functional specialization of presynaptic Cav2.3 Ca2+ channels. Neuron, 39: 483-496. (PubMed)

Remy, S., Urban, B.W., Elger, C.E., Beck, H. (2003) Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats. Eur. J. Neurosci., 17: 2648-2658. (PubMed)

Ellerkmann, R., Remy, S., Chen, J., Sochivko, D., Elger, C.E., Urban, B.W., Becker, A., Beck, H. (2003) Molecular and functional changes in voltage-dependent Na+ channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience, 119: 323-333. (pdf)

Remy, S., Gabriel, S., Urban, B.W., Dietrich, D., Lehmann, T.-N., Elger, C.E., Heinemann, U., Beck, H. (2003) A novel mechanism underlying drug resistance in chronic epilepsy. Ann. Neurol., 53: 469-479. (PubMed)

Sochivko, D., Chen, J., Becker, A., Beck, H. (2003) Blocker-resistant Ca2+ currents in rat CA1 hippocampal pyramidal neurons. Neuroscience, 116: 629-638. (pdf)

2002

Fasen, K., Beck, H., Elger, C.E., Lie, A.A. (2002) Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. J. Neuropathol. Exp. Neurol., 61: 903-913. (pdf)

Wellmer, J., Su, H., Beck, H., Yaari, Y. (2002) Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus. Eur. J. Neurosci.,16: 259-266. (PubMed)

Becker, A.J., Chen, J., Paus, S., Normann, S., Beck, H., Elger, C.E., Wiestler, O.D., Blümcke, I. (2002) Transcriptional profiling in human epilepsy: expression array and single cell real-time qRT-PCR analysis reveal distinct cellular gene regulation. Neuroreport,13: 1327-1333. (PubMed)

Sochivko, D., Pereverzev, A., Smyth, N., Gissel, C., Schneider, T., Beck, H. (2002) The Cav2.3 Ca2+ channel subunit contributes to R-type Ca2+ currents in murine hippocampal and neocortical neurones. J. Physiol., 542: 699-710. (PubMed)

Su, H., Sochivko, D., Becker, A., Chen, J., Jiang, Y., Yaari, Y., Beck, H. (2002) Upregulation of a T-type Ca2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus. J. Neurosci., 22: 3645-3655. (PubMed)

Kudin, A.P., Kudina, T.A., Seyfried, J., Vielhaber, S., Beck, H., Elger, C.E., Kunz, W.S. (2002) Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus. Eur. J. Neurosci., 15: 1105-1114. (PubMed)

Jeub, M., Beck, H., Siep, E., Rüschenschmidt, C., Speckmann, E.-J., Ebert, U., Potschka, H., Freichel, C., Reissmüller, E., Löscher, W. (2002) Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats. Neuropharmacology, 42: 107-116. (pdf)

Yaari, Y., Beck, H. (2002) “Epileptic neurons” in temporal lobe epilepsy. Brain Pathol., 12: 234-239. (PubMed)

2001

Riazanski, V., Becker, A., Chen, J., Sochivko, D., Lie, A., Wiestler, O.D., Elger, C.E., Beck, H. (2001) Functional and molecular analysis of transient voltage-dependent K+ currents in rat hippocampal granule cells. J. Physiol., 537: 391-406. (PubMed)

Chen, J., Sochivko, D., Beck, H., Marechal, D., Wiestler, O.D., Becker, A.J. (2001) Activity-induced expression of common reference genes in individual CNS neurons. Lab. Invest., 81: 913-916. (PubMed)

Ellerkmann, R.K., Riazanski, V., Elger, C.E., Urban, B.W., Beck, H. (2001) Slow recovery from inactivation regulates the availability of voltage-dependent Na+ channels in hippocampal granule cells, hilar neurons and basket cells. J. Physiol., 532: 385-397. (PubMed)

Grunwald, T., Beck, H., Elger, C.E. (2001) Bausteine des Gedächtnisses: Untersuchungen der menschlichen Hippokampusfunktion in-vivo und in-vitro. Neuroforum, 3: 114-121. (pdf)

2000

Kunz, W.S., Kudin, A.P., Vielhaber, S., Blümcke, I., Zuschratter, W., Schramm, J., Beck, H., Elger, C.E. (2000) Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy. Ann. Neurol., 48: 766-773. (PubMed)

Söhl, G., Güldenagel, M., Beck, H., Teubner, B., Traub, O., Gutiérrez, R., Heinemann, U., Willecke, K. (2000) Expression of connexin genes in hippocampus of kainate-treated and kindled rats under conditions of experimental epilepsy. Brain Res. Mol. Brain Res., 83: 44-51. (PubMed)

Beck, H., Goussakov, I.V., Lie, A., Helmstaedter, C., Elger, C.E. (2000) Synaptic plasticity in the human dentate gyrus. J. Neurosci., 20: 7080-7086. (PubMed)

Goussakov, I.V., Fink, K., Elger, C.E., Beck, H. (2000) Metaplasticity of mossy fiber synaptic transmission involves altered release probability. J. Neurosci., 20: 3434-3441. (PubMed)

Nägerl, U.V., Mody, I., Jeub, M., Lie, A.A., Elger, C.E., Beck, H. (2000) Surviving granule cells of the sclerotic human hippocampus have reduced Ca2+ influx because of a loss of calbindin-D28k in temporal lobe epilepsy. J. Neurosci., 20: 1831-1836. (PubMed)

Blümcke, I., Becker, A.J., Klein, C., Scheiwe, C., Lie, A.A., Beck, H., Waha, A., Friedl, M.G., Kuhn, R., Emson, P., Elger, C., Wiestler, O.D. (2000) Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. J. Neuropathol. Exp. Neurol., 59: 1-10. (pdf)

Lie, A.A., Becker, A., Behle, K., Beck, H., Malitschek, B., Conn, P.J., Kuhn, R., Nitsch, R., Plaschke, M., Schramm, J., Elger, C.E., Wiestler, O.D., Blümcke, I. (2000) Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann. Neurol., 47: 26-35. (PubMed)

Schumacher, T.B., Beck, H., Steffens, R., Blümcke, I., Schramm, J., Elger, C.E., Steinhäuser, C. (2000) Modulation of calcium channels by group I and group II metabotropic glutamate receptors in dentate gyrus neurons from patients with temporal lobe epilepsy. Epilepsia, 41: 1249-1258. (PubMed)

Elger, C.E., Beck, H. (2000) Anfallserkrankungen. In: Lehrbuch der Pathophysiologie. Eds. Fölsch, U.R., Kochsieck, K., Schmidt, R.F. Berlin, Heidelberg: Springer Verlag, pp. 497-510.

1999

Grunwald, T., Beck, H., Lehnertz, K., Blümcke, I., Pezer, N., Kurthen, M., Fernandez, G., Van Roost, D., Heinze, H.J., Kutas, M., Elger, C.E. (1999) Evidence relating human verbal memory to hippocampal N-methyl-D-aspartate receptorss. Proc. Natl. Acad. Sci. USA, 96: 12085-12089. (PubMed)

Kudin, A., Vielhaber, S., Beck, H., Elger, C.E., Kunz, W.S. (1999) Quantitative investigation of mitochondrial function in single rat hippocampal slices: a novel application of high-resolution respirometry and laser-excited fluorescence spectroscopy. Brain Res. Brain Res. Protoc., 4: 329-334. (PubMed)

Blümcke, I, Beck, H., Lie, A.A., Wiestler, O.D. (1999) Molecular neuropathology of human mesial temporal lobe epilepsy. Epilepsy Res., 36: 205-223. (pdf)

Jeub, M., Lie, A., Blümcke, I., Elger, C.E., Beck, H. (1999) Loss of dynorphin-mediated inhibition of voltage-dependent Ca2+ currents in hippocampal granule cells isolated from epilepsy patients is associated with mossy fiber sprouting. Neuroscience, 94: 465-471. (pdf)

Lie, A.A., Blümcke, I., Volsen, S.G., Wiestler, O.D., Elger, C.E., Beck, H. (1999) Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy. Neuroscience, 93: 449-456. (pdf)

Grunwald, T., Beck, H., Lehnertz, K., Blümcke, I., Pezer, N., Kutas, M., Kurthen, M., Karakas, H.M., Van Roost, D., Wiestler, O.D., Elger, C.E. (1999) Limbic P300s in temporal lobe epilepsy with and without Ammon’s horn sclerosis. Eur. J. Neurosci., 11: 1899-1906. (PubMed)

Lie, A.A., Blümcke, I., Beck, H., Wiestler, O.D., Elger, C.E., Schoen, S.W. (1999) 5′-Nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain. J. Neuropathol. Exp. Neurol., 58: 451-458. (PubMed)

Becker, A.J., Gillardon, F., Blümcke, I., Langendörfer, D., Beck, H., Wiestler, O.D. (1999) Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus. Brain Res. Mol. Brain Res., 67:172-176. (PubMed)

Reckziegel, G., Beck, H., Schramm, J., Urban, B.W., Elger, C.E. (1999) Carbamazepine effects on Na+ currents in human dentate granule cells from epileptogenic tissue. Epilepsia, 40: 401-407. (PubMed)

Kunz, W.S., Goussakov, I.V., Beck, H., Elger, C.E. (1999) Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats. Brain Res., 826: 236-242. (pdf)

Blümcke, I., Beck, H., Suter, B., Hoffmann, D., Födisch, H.J., Wolf, H.K., Schramm, J., Elger, C.E., Wiestler, O.D. (1999) An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy. Acta Neuropathol., 97: 31-39. (pdf)

Beck, H., Steffens, R., Heinemann, U., Elger, C.E. (1999) Ca2+-dependent inactivation of high-threshold Ca2+ currents in hippocampal granule cells of patients with chronic temporal lobe epilepsy. J. Neurophysiol., 82: 946-954. (PubMed)

1998

Lie, A.A., Blümcke, I., Beck, H., Schramm, J., Wiestler, O.D., Elger, C.E. (1998) Altered patterns of Ca2+/calmodulin-dependent protein kinase II and calcineurin immunoreactivity in the hippocampus of patients with temporal lobe epilepsy. J. Neuropathol. Exp. Neurol., 57: 1078-1088. (PubMed)

Beck, H., Steffens, R., Elger, C.E., Heinemann, U. (1998) Voltage-dependent Ca2+ currents in epilepsy. Epilepsy Res., 32: 321-332. (pdf)

Schumacher, T.B., Beck, H., Steinhäuser, C., Schramm, J., Elger, C.E. (1998) Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy. Epilepsia, 39: 355-363. (PubMed)

Reckziegel, G., Beck, H., Schramm, J., Elger, C.E., Urban, B.W. (1998) Electrophysiological characterization of Na+ currents in acutely isolated human hippocampal dentate granule cells. J. Physiol., 509: 139-150. (PubMed)

1997

Dietrich, D., Beck, H., Kral, T., Clusmann, H., Elger, C.E., Schramm, J. (1997) Metabotropic glutamate receptors modulate synaptic transmission in the perforant path: pharmacology and localization of two distinct receptors. Brain Res., 767: 220-227. (pdf)

Scheffler, B., Faissner, A., Beck, H., Behle, K., Wolf, H.K., Wiestler, O.D., Blümcke, I. (1997) Hippocampal loss of tenascin boundaries in Ammon’s horn sclerosis. Glia, 19: 35-46. (PubMed)

Beck, H., Steffens, R., Heinemann, U., Elger, C.E. (1997) Properties of voltage-activated Ca2+ currents in acutely isolated human hippocampal granule cells. J. Neurophysiol., 77: 1526-1537. (PubMed)

Beck, H., Clusmann, H., Kral, T., Schramm, J., Heinemann, U., Elger, C.E. (1997) Potassium currents in acutely isolated human hippocampal dentate granule cells. J. Physiol., 498: 73-85. (PubMed)

1996

Blümcke, I., Beck, H., Scheffler, B., Hof, P.R., Morrison, J.H., Wolf, H.K., Schramm, J., Elger, C.E., Wiestler, O.D. (1996) Altered distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy. Acta Neuropathol., 92: 576-587. (pdf)

Blümcke, I., Beck, H., Nitsch, R., Eickhoff, C., Scheffler, B., Celio, M.R., Schramm, J., Elger, C.E., Wolf, H.K., Wiestler, O.D. (1996) Preservation of calretinin-immunoreactive neurons in the hippocampus of epilepsy patients with Ammon’s horn sclerosis. J. Neuropathol. Exp. Neurol., 55: 329-341. (PubMed)

Beck, H., Blümcke, I., Kral, T., Clusmann, H., Schramm, J., Wiestler, O.D., Heinemann, U., Elger, C.E. (1996) Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsy. Epilepsia, 37: 892-901. (PubMed)

1995

Spenger, C., Beck, H., Studer, L., Evtouchenko, L., Seiler, W. (1995) Transplantation fötalen mesenzephalen Gewebes. Therapiewoche Schweiz, 11: 80-84.

1993

Heinemann, U., Albrecht, D., Beck, H., Ficker, E., Nixdorf, B., Stabel, J., von Haebler, D. (1993) Potassium homeostasis and epileptogenesis in the immature hippocampus. In: Epileptogenic and excitotoxic mechanisms. Eds. Avanzini, G., Fariello, R., Heinemann, U., Mutani., R. London: John Libbey, pp. 99-106.

1992

Wieser, H.G., Beck, H. (1992) Improvement of medically refractory temporal lobe complex partial epilepsy with dextromethorphan. J. Epilepsy, 5: 246-247.

Beck, H., Ficker, E., Heinemann, U. (1992) Properties of two voltage-activated potassium currents in acutely isolated juvenile rat dentate gyrus granule cells. J. Neurophysiol., 68: 2086-2099. (PubMed)

Heinemann, U., Beck, H., Dreier, J.P., Ficker, E., Stabel, J., Zhang, C.L. (1992) The dentate gyrus as a regulated gate for propagation of epileptiform activity. In: The dentate gyrus and its role in seizures. Eds. Ribak, C.E., Gall, C.M., Mody, I. Epilepsy Res. Suppl., 7: 273-280. (PubMed)

Heinemann, U., Albrecht, D., Beck, H., Ficker, E., von Haebler, D., Stabel, J. (1992) Delayed K+ regulation and K+ current maturation as factors of enhanced epileptogenicity during ontogenesis of the hippocampus of rats. In: Molecular Neurobiology of Epilepsy. Eds. Engel Jr, J., Wasterlain, C., Cavalheiro, E.A., Heinemann, U., Avanzini, G. Epilepsy Res. Suppl., 9: 107-114. (PubMed)

 

 

Heinemann, U., Beck, H., Draguhn, A. (in press) Antiepileptic Drugs. Neuropharmacology, xx: xx-xx.