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Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug

Posted on 15. June 2018 by Kristian Reichelt

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Selective aptamer-based control of intraneuronal signalingImpaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human NaV1.1 mutation

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The AG Mody develped a high-fidelity dark quencher genetically encodable voltage indicator (dqGEVI) for recordings of neuronal activity with outstanding temporal resolution
The AG Schwarz developed a closed loop, deep learning-based real time posture detection tool allowing to autonomously conduct behavioral experiments.
The AG Schwarz was part of an international collaboration coordinated by Prof. Valery Grinevich from the Central Institute of Mental Health in Mannheim and published a research article on the role of the neuropeptide oxytocin in social interactions.

Contact:

Nicole Schönfelder
University of Bonn Medical Center |
Life and Brain
Venusberg-Campus 1
Building 76
53127 Bonn
Tel.: +49-228-6885 276
E-Mail: Nicole.Schoenfelder@ukbonn.de