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Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug

Posted on 15. June 2018 by Kristian Reichelt

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Selective aptamer-based control of intraneuronal signalingImpaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human NaV1.1 mutation

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The AG Schwarz developed a closed loop, deep learning-based real time posture detection tool allowing to autonomously conduct behavioral experiments.

In general, animal behavior can be described as the neuronal-driven sequence of reoccurring postures through time. Current technologies enable offline pose estimation with high spatio-temporal resolution, however to understand complex behaviors, it is necessary to correlate the behavior with neuronal activity in real-time. […]

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The AG Schwarz was part of an international collaboration coordinated by Prof. Valery Grinevich from the Central Institute of Mental Health in Mannheim and published a research article on the role of the neuropeptide oxytocin in social interactions.

From the softest caress to the harshest blow, touch lies at the heart of our sensory experience of the world and shapes the way we perceive it, especially during intimate interactions with other humans. The sense of touch is one of the central forms of perceptual experience, although it has often been overshadowed by vision in philosophy, scientific research and psychology. […]

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The AG Schwarz was part of a collaboration with the group of Prof. Patrik Krieger from the Ruhr University of Bochum and published a paper on Cortical layer 6 control of sensory responses in higher-order thalamus.

Thalamic activity is regulated by corticothalamic feedback from layers 5B and 6. The nature of these feedback systems differs, one difference being that whereas layer 5 provides ‘driver’ input, the layer 6 input is thought to be ‘modulatory’. To selectively study the importance of the layer 6 corticothalamic (L6 CT) projection, a transgenic mouse line was used in which layer 6 cells projecting to posterior medial thalamus (POm) were targeted for expression of channelrhodopsin-2 and in vivo electrophysiology recordings were done in urethane-anaesthetized mice. […]

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Institute of Experimental Epileptology and Cognition Research
University of Bonn Medical Center | Life and Brain
Venusberg Campus 1
Building 76
53127 Bonn

Tel.: +49-228-6885 215
Fax.: +49-228-6885 296