Rose Group

Circuit Mechanisms of Behavior

Chronic functional in vivo two-photon imaging – from neuronal populations to synapses

We are what we remember: Learning and memory are fundamental building blocks of our identity and knowledge of the past informs our behavior in the present. The persistence of memory is one of the most striking and defining features of cognition. However, the neural circuits supporting normal processing in the brain appear to constantly rearrange themselves. But how can stable memory arise if network structure itself seemingly is in constant flux?

In my newly established group at the IEECR we study the stability and stabilisation of the neural code in sensation and memory. We address the “stability-plasticity-conundrum” in the mouse visual system, retrosplenial cortex, and hippocampal formation on multiple scales, ranging from the synaptic to the circuit level.

We focus on establishing novel densely quantified behavioral paradigms, emphasizing unrestrained behavior, longitudinal synapse- and circuit-level optophysiology, and the use and further development of both miniaturized and bench-top two-photon microscopy. Ultimately, we aim to better understand the circuit dynamics underlying complex visually guided behavior and learning and memory.

3d-tracked closed-loop visual search / foraging / spatial memory tasks

If you are interested in studying stability and plasticity in distributed circuits using cutting edge approaches – Join our lab!

Check our twitter: @trose_neuro

Layer 5 neurons projecting to superior colliculus in the mouse visual cortex (in vivo two-photon image stack)